METHOD AND SYSTEM FOR MULTIPLE DOT PLOT ANALYSIS

摘要

The present invention relates to a method for analyzing a genome sequence, and particularly relates to a genome analysis method for modifying existing reference genome sequence information. More particularly, the present invention relates to a method for quickly and efficiently implementing gap closing of an existing reference genome by comparing and analyzing an assembled sequence of a genome of a test sequence with the existing reference genome sequence via a multiple dot plot analysis method using a de novo assembly, and accordingly enhancing completeness of the reference genome through modification of sequence information of the existing reference genome. In addition, the present invention relates to a method for identifying mutation of the genome sequence of a test object by comparing the reference sequence modified according to the genome analysis method and the de novo assembled test sequence. In particular, the present invention relates to a method for identifying haplotype-specific gene mutations.