8-- 8-HYDROXY-QUINOLINE DERIVATIVES

摘要

The present invention relates to compounds of the general formula (I) and their pharmaceutically acceptable salts. (In the general formula (I), R ₁ represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower cycloalkyl group, aralkyl represents an kilgi or heterocyclic ring, wherein the group is substituted at the ortho, meta and / or para position by one, two, three or four electronic machine or an electron donor; R ₂ is A hydrogen atom, a lower alkyl group, an aryl group, an aralkyl group or a heterocyclic group, which group is optionally substituted with one or more halogen atoms; R ₃ represents a lower alkyl group, an aryl group, an aralkyl group or a heterocyclic group, which group is optionally substituted at the ortho, meta or para position with 1, 2, 3 or 4 electron withdrawing or electron-donating groups; R ₄ is A hydrogen atom, a lower alkyl group or all acidic functional groups; And n is 1 or 2). The compounds of the present invention can be used as medicines for the treatment of diseases mainly related to neurogenic and / or oxidative stress.