Novel spiroquinone compound method for preparing the same and pharmaceutical composition for use in preventing or treating neurological diseases containing the same as an active ingredient

摘要

TECHNICAL FIELD The present invention relates to a novel spiroquinone derivative compound, a process for producing the same, and a pharmaceutical composition for preventing or treating a neurological disease containing the compound as an active ingredient. The present invention relates to a novel spiroquinone derivative compound, a stereoisomer thereof, Acceptable salts can excellently suppress microglial activation and have excellent inhibitory activity against acetylcholinesterase, JNK1, JNK2, and JNK3. In addition, RKK5, CDK3 / cyclin E, PKN2 / PRK2, Haspin, STK25 / YSK1, ARK5 / NUAK1, PKCb2, CDK2 / cyclin O, DAPK1, PKCa, CDK1 / cyclin B, MST3 / STK24, and TLK1 The present inventors have found that a novel spiroquinone derivative compound, a stereoisomer thereof, or a derivative thereof can be obtained by confirming a significant enzyme inhibitory activity and exhibiting an effect of inhibiting cell death. Significant health for the prevention and improvement of the pharmaceutical composition or neurological diseases for the prevention and treatment of nervous system disorders, containing acceptable salt as an effective ingredient can be effectively used as a food composition.