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Pharmaceutical composition of sustained-release solid dispersion of pelubiprofen and method for producing the same
Pharmaceutical composition of sustained-release solid dispersion of pelubiprofen and method for producing the same
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机译:贝洛洛芬缓释固体分散体的药物组合物及其制备方法
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摘要
The present invention relates to a sustained-release solid dispersion preparation of pelubiprofen and, more specifically, to a sustained-release solid dispersion preparation of pelubiprofen comprising Eudragit® RL PO, Eudragit® RS PO, and aminoclay. Eudragit® RL PO and Eudragit® RS PO in the present invention are pH-independent polymer mixtures, which are insoluble but may swell at physiological pH, and thus when exposed in an aqueous medium, regulates penetration of a medium inside a matrix. In addition, aminoclay is a microenvironment pH regulator having a cationic layered nanosheet structure, which is effective in regulating a drug release rate in a solid matrix structure. Accordingly, the sustained-release solid dispersion preparation of pelubiprofen according to the present invention shows continuous drug release effects in the gastrointestinal tract and reduces the frequency of administration, and thus can be beneficially used in the future.
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