HMGA2 Method for Producing Reprogrammed Induced Neural Stem Cells from Non-Neuronal Cells Using HMGA2

摘要

The present invention relates to a method for producing reprogrammed induction neural stem cells from differentiated cells. Since the induction neural stem cells can be produced from non-neuronal cells by using only two inducers such as SOX2 and HMGA2 as the inducing factors, the induction neural stem cells according to the present invention can produce four inducers, five inducers Can induce more efficient induction of neural stem cells. In addition, since the induction efficiency and the proliferation power of the SOX2 gene are remarkably superior to those of the SOX2 gene alone, the possibility of using the SOX2 gene for therapeutic purposes can be increased.