GVHD CD4 ANTI CD4 ANTIBODIES TO PREVENT IN PARTICULAR GRAFT - VESUS - HOST - DISEASEGVHD

摘要

The present invention is directed to a method for the treatment of cancer, among others, comprising the steps of: a) culturing a cell graft containing immune cells with an anti-CD4 antibody, wherein said culturing is carried out for 1 to 7 days; and b) removing unbound antibody from said graft To an in vitro method of transforming a cell graft containing an immune cell, as well as to a corresponding modified graft and a method of using the same. The present invention also relates to a method for the treatment and / or prophylaxis of CD4 (CD4) antibodies, such as anti-human CD4 antibodies, which have a reduced number of potential T-cell epitopes but which include heavy chain immunoglobulin variable region (VH) and light chain immunoglobulin variable region Wherein at least one T cell epitope located outside the CDRs of the immunoglobulin variable region is a variant of an immunoglobulin variable region that is reactive to a CD4 human leukocyte antigen to provide an anti- Region. It is preferred that the mode of action and specificity of the anti-CD4 antibody is not affected by the modification (s).