-2 Composition for preventing or treating diabetes and method for screening antidiabetic agents using tetraspanin-2

摘要

TECHNICAL FIELD The present invention relates to a composition for preventing or treating diabetes using tetraspanin-2 and a method for screening a therapeutic agent for diabetes, and more particularly, to a composition for preventing or treating diabetes by using tetrasparenin-2 (TSPAN2) A pharmaceutical composition for preventing or treating diabetes comprising: (a) contacting a test substance with a cell expressing a TSPAN2 gene; (b) measuring the level of TSPAN2 gene expression in a control cell not in contact with the test substance; And (c) screening a test substance that reduces the level of TSPAN2 gene expression as compared to a control cell, as a candidate for a diabetes therapeutic agent. The composition and screening method of the present invention are based on the role of TSPAN2, which promotes apoptosis of pancreatic beta cells through JNK and β-catenin under hyperglycemic conditions, and is a novel mechanism of action that inhibits the expression or activity of TSPAN2 protein And can be usefully used for developing therapeutic agents.