A method and system for non-invasive automatic estimation of shear modulus and viscosity of biological tissue from shear wave imaging is disclosed. Shear wave images are acquired to evaluate the mechanical characteristics of the organ of a patient. Shear wave propagation of tissue in the shear wave images is simulated based on the shear modulus and viscosity values for the tissue using a computation module of shear wave propagation. The simulated shear wave propagation is compared with the shear wave propagation observed in the tissue shear wave images using a cost function. The patient-specific shear modulus and viscosity values for the tissue are estimated to optimize the cost function to compare the observed shear wave propagation to the simulated shear wave propagation.
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