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Composition and method for detecting a diagnostic marker for renal cell carcinoma

机译:用于检测肾细胞癌的诊断标志物的组合物和方法

摘要

The present invention relates to a composition for diagnosing renal cancer and a diagnostic marker detecting method. More particularly, the present invention relates to glycyl-tRNA synthetase (GRS), histidyl-tRNA synthetase (HRS), and aminoacyl-tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1) And a method for detecting the marker from a sample obtained from a subject to provide information necessary for diagnosing kidney cancer. The present invention also provides a method for detecting a marker of kidney cancer, comprising the steps of: . The inventive kidney cancer diagnostic markers of GRS, HRS and AIMP1 have increased expression levels in the serum of patients with kidney cancer compared to normal control. Thus, the presence or absence of kidney cancer can be determined accurately and quickly by measuring the expression levels of one or more markers selected from the group consisting of GRS, HRS and AIMP1.
机译:本发明涉及用于诊断肾癌的组合物和诊断标志物检测方法。更具体地,本发明涉及糖基-tRNA合成酶(GRS),组氨酸-tRNA合成酶(HRS)和与氨酰基-tRNA合成酶复合物相互作用的多功能蛋白1(AIMP1),以及从由受试者提供诊断肾癌所需的信息。本发明还提供了一种检测肾癌标志物的方法,其包括以下步骤:与正常对照相比,本发明的GRS,HRS和AIMP1的肾癌诊断标志物在肾癌患者的血清中表达水平升高。因此,可以通过测量选自GRS,HRS和AIMP1的一种或多种标志物的表达水平来准确而迅速地确定是否存在肾癌。

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