Anti-thrombotic composition comprising serine protease extracted from Marphysa Sanguinea

摘要

The present invention relates to an antioxidant composition, a pharmaceutical composition and a food composition comprising a serine protease separated from a rockwool crab. The serine protease isolated from the rockwool lug according to the present invention exhibits indirect fibrinolytic activity at a wide pH and temperature, has no cytotoxicity, exhibits anticoagulant effect and cell stability. The direct thrombolytic ability in the dissolution action of the thrombolytic agent is very good, but the activity thereof is very good. However, the use of the serine protease of the present invention is not sufficient in that the thrombin dissolution ability of the present invention is not so large and the indirect thrombolysis And the side effects of conventional thrombolytic agents such as bleeding can be overcome. Therefore, it can be effectively used as an antithrombotic pharmaceutical composition and food composition effective for diseases such as hypertension, heart disease, stroke, myocardial infarction and the like due to thrombus and platelet aggregation.