A method of preparing hollow inorganic nanocarriers for reserving gene molecules and its use

摘要

The present invention relates to a method for producing hollow nanoparticles for carrying a dielectric material and a use thereof and, in order to maximally increase the loading capacity of a dielectric substance such as siRNA, which is negatively charged, the surface of the hollow nanoparticles is modified, When the dielectric nanoparticles are loaded on the hollow nanoparticles, the internal capacity of the hollow nanoparticles is reduced to increase the loading capacity of the dielectric material. The hollow nanoparticles produced by the production method of the present invention effectively carry siRNA and induce the release of siRNA continuously over the course of a few weeks, effectively silencing genes such as Plekho-1, which inhibits bone differentiation, And can be used for various gene therapies.