POLYMORPHES 2- (4- (2- (1-Iso-propyl-3-methyl-1H-1,2,4-triazole-5-yl) -5,6-dihydrobenzo F imidazo 1,2-D 1,4 OXAZEPIN-9-IL) -1H-PYRAZOL-1-IL) -2-METHYLPROPANAMIDE, METHODS FOR THEIR PRODUCTION AND PHARMACEUTICAL APPLICATIONS

摘要

The present invention relates to crystalline polymorphs of (2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide (GDC-0032, taselisib), methods of use, and processes of preparing thereof.