首页> 外国专利> COMPOSITION OF DELIVERY SYSTEM BASED ON CONJUGATE FOR RNA-INTERFERENCE POLYNUCLEOTIDE DELIVERY TO LIVER CELL AND PROCESS FOR ITS PREPARATION

COMPOSITION OF DELIVERY SYSTEM BASED ON CONJUGATE FOR RNA-INTERFERENCE POLYNUCLEOTIDE DELIVERY TO LIVER CELL AND PROCESS FOR ITS PREPARATION

机译：基于结合物的RNA干扰多核苷酸转运至肝细胞的输送系统的组成及其制备方法

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FIELD: biotechnology.;SUBSTANCE: RNA-interference polynucleotide is administered in conjunction with a targeting melittin peptide modified by asialoglycoprotein (ASGPr) receptors, for delivery to a mammal liver cell.;EFFECT: functional penetration through liver cells membranes to provide RNA-interference polynucleotide movement into the cells.;20 cl, 5 dwg, 11 tbl, 18 ex

机译：领域：生物技术;研究对象：RNA干扰多核苷酸与脱唾液酸糖蛋白（ASGPr）受体修饰的靶向蜂毒肽一起给药，以递送至哺乳动物肝细胞;效果：通过肝细胞膜的功能性渗透以提供RNA干扰。多核苷酸运动进入细胞。; 20 cl，5 dwg，11 tbl，18 ex

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公开/公告号RU2623160C9

专利类型
公开/公告日2018-02-26

原文格式PDF
申请/专利权人 ERROUKHED FARMASYUTIKALZ INK.;
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申请/专利号RU20130117285
发明设计人 ROZEMA DEVID B. (US);LYUIS DEVID L. (US);VEJKFILD DARREN KH. (US);KITAS ERIK A. (CH);KHADVIGER FILIPP (DE);VOLF DZHON A. (US);ROEL INGO (DE);MOR PITER (CH);KHOFMANN TORSTEN (DE);ZHAN-KHOFFMAN KERSTIN (DE);MYULLER KHANS MARTIN (DE);OTT GYUNTER (DE);BLOKHIN ANDREJ V. (US);BENSON DZHONATAN D. (US);KARLSON DZHEFFRI S. (US);
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申请日2011-12-16
分类号C07K14/435;C07K19;C12N15/11;A61K31/713;A61P1/16;
国家 RU
入库时间 2022-08-21 12:35:59

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