METHOD OF SYNTHESIS OF INDOLO1',7':1,2,3PIRROLO3',4':6,7AZEPINO4,5-BINDOL-1,3(2H,10H)-DIONE

摘要

FIELD: medicine; pharmaceuticals.;SUBSTANCE: invention refers to the new method for the preparation of indolo[1',7':1,2,3]pyrrolo[3',4':6,7]azepino[4,5-b]indole-1,3(2H,10H)-dione, which is the starting material for the preparation of the potential antitumor preparation of 6-[(4-methyl-1-1-piperazinyl)methyl]-indolo[1',7':1,2,3]pyrrolo[3',4':6,7]azepino[4,5-6]indole-1,3(2H,10H)-dione). Method includes the steps of introducing the protecting group along the indole nitrogen atom, the subsequent dehydrogenation step under the action of 2,3-dichloro-5,6-dicyanobenzoquinone, and the step of protective group removal. ; .;EFFECT: claimed method allows to increase the yield of the final product more than twice as compared with the known method.;1 cl, 6 ex