首页> 外国专利> RECOMBINATIONAL CARTRIDGE CONTAINING THE EP153R AND EP364R GENES OF THE CONGO (KK-262) STRAIN OF THE AFRICAN SWINE FEVER VIRUS AND RECOMBINANT ΔCONGOCD2V STRAIN OF THE AFRICAN SWINE FEVER VIRUS

RECOMBINATIONAL CARTRIDGE CONTAINING THE EP153R AND EP364R GENES OF THE CONGO (KK-262) STRAIN OF THE AFRICAN SWINE FEVER VIRUS AND RECOMBINANT ΔCONGOCD2V STRAIN OF THE AFRICAN SWINE FEVER VIRUS

机译:包含非洲猪瘟病毒刚果(KK-262)菌株和非洲猪瘟病毒重组ΔCONGOCD2V菌株的EP153R和EP364R基因的重组载体

摘要

FIELD: veterinary.;SUBSTANCE: invention relates to the field of veterinary virology and genetic engineering and concerns a recombinant strain of the African swine fever virus. ΔCongoCD2v strain of the African swine fever (ASF) virus with the deletion of the gene EP402R (CD2v) containing the EGFP reporter gene under the control of the p72 promoter is suggested. Claimed strain was obtained from the KK-262 strain of the ASF virus by homologous recombination and deposited in the collection of microorganism cultures of the Federal Research Centre of Virology and Microbiology under №3148.;EFFECT: strain can be used to study the role of the CD2v protein of the ASF virus in the virus reproduction in cell cultures, in susceptible animals, as well as its functions in modulating the immune response.;1 cl, 1 dwg, 1 tbl, 3 ex
机译:发明领域本发明涉及兽医病毒学和基因工程领域,涉及非洲猪瘟病毒的重组株。有人建议在非洲猪瘟(ASF)病毒的ΔCongoCD2v株中删除包含在p72启动子控制下的EGFP报告基因的基因EP402R(CD2v)。要求保护的菌株是通过同源重组从ASF病毒的KK-262菌株中获得的,并存放在美国联邦病毒与微生物学研究中心的微生物培养物中,编号为3148。效果:该菌株可用于研究ASF病毒的作用。细胞培养,易感动物中的ASF病毒CD2v蛋白在病毒繁殖中的表达及其在调节免疫应答中的功能。1cl,1 dwg,1 tbl,3 ex

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