LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1 (LFA-1) INHIBITOR, METHODS FOR PRODUCTION AND POLYMORPH THEREOF

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to a process for the preparation and purification of a compound of formula I or a salt thereof, which is an effective inhibitor for the treatment of mediated lymphocyte function-associated antigen-1 (LFA-1) diseases, comprising steps of: a) carrying out hydrolysis of the compound of formula AA: where R is a carbon-containing fragment, with a base in a two-phase medium; and b) isolating said compound of formula I or a salt thereof, said process further comprising purifying said compound of formula I by recrystallisation with an aqueous solution of acetone. .;EFFECT: technical result is the preparation of a compound of formula I with an optical purity of about 98%.;13 cl, 10 dwg, 1 tbl, 11 ex