DOUBLE-TARGET MUTEIN MUR6S4TR OF TRAIL, AND PREPARATION METHOD AND USE THEREOF

摘要

The present invention belongs to the field of genetic engineering drugs, and provides a mutein MuR6S4TR of TRAIL, and a preparation method and use thereof. The N-terminal positions 2-11 of the amino acid sequence of the mutein consist of the transmembrane peptide sequence RRRRRR (R6) and the binding sequence AVPI of the apoptosis inhibitor XIAP, the positions 12-169 are the TRAIL protein peptide segment (124-281 aa), and the specific sequence is as shown in SEQ ID NO: 2.