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FIBROBLASTS CELLULAR MODEL FOR ASSESSING EFFICACY OF CANCER TREATMENTS BY SHH/PTCH PATHWAY ANTAGONISTS
FIBROBLASTS CELLULAR MODEL FOR ASSESSING EFFICACY OF CANCER TREATMENTS BY SHH/PTCH PATHWAY ANTAGONISTS
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机译:SHH / PTCH通路拮抗剂评估成纤维细胞模型在癌症治疗中的作用
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摘要
A cellular model is described that targets dysregulation or inappropriate activation of the Sonic Hedgehog/Patched (SHH/PTCH) pathway. Also described, is a screening method using this cellular model to screen for pharmacological compounds that can treat or prevent skin cancer, in particular, Basal Cell Carcinoma, (BCC) lesions.
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