Sample preparation for ionisation with matrix-assisted laser desorption

摘要

A simplified sample preparation on a sample support for ionisation with laser desorption (MALDI or LDCI, for example) is proposed, whereby a homogeneous crystallisation of the matrix material is possible, even if a large quantity of analyte material is deposited, serving as the source of the analyte molecules. The method includes depositing the analyte material onto a deposition site, providing a sample site which is intended as the substrate for a matrix crystal layer at a distance from the deposition site, and establishing a liquid communication between the deposition site and the sample site. The invention also relates to a device for the preparation of samples for ionisation with matrix-assisted laser desorption, and to a sample support.