One kind is provided for high-power cooling system for computer case comprising: casing; At least one main air duct is formed in casing with the first opening and the second opening, the first heat generating component, one second heat generating component and at least one first fan, it is mounted at least one main air duct, wherein the first fan is mounted on the first fever assembly, with the second heat generating component; The outlet of first fan enters the main air duct of the first opening of main air duct, flows through the second heat generating component with the first heat generating component, air-flow is faced, the entrance of first fan, outlet, the first fan, it is sequentially connected with the first heat generating component, and finally discharge the main air duct cabinet of cabinet from the second opening.
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