P27 TYROSINE PHOSPHORYLATION AS A MARKER OF CDK4 ACTIVITY AND METHODS OF USE THEREOF

摘要

Compositions and methods for the treatment of malignancy are disclosed. Specifically, the disclosure provides a method for treating cancer comprises assessing tyrosine 88 (Y88) phosphorylation (pY88) levels in p27 in a biological sample comprising cancer cells from a subject, and stratifying pY88 phosphorylation levels as 0, 1, 2 or 3 as compared to pY88 phosphorylation levels observed in control tissues; where a level of 0 indicates no detectable sensitivity to cyclin-dependent kinase 4 (cd4k) inhibition; a level of 1, low or no detectable sensitivity; and a level of 2 or 3, indicates detectable sensitivity to cdk4 inhibition. Further provided is a kit for practicing the method.