RETROVIRAL VECTORS CONTAINING A REVERSE ORIENTATION HUMAN UBIQUITIN C PROMOTER

摘要

In certain embodiments a recombinant retroviral vector is provided where the vector comprises a human ubiquitin C (UBC) promoter operably linked to a transgene where the promoter and the transgene are in a reverse orientation so that the direction of transcription of the transgene from the promoter is oriented towards a 5′ long terminal repeat (LTR) of the vector.