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NORRIN REGULATION OF JUNCTION PROTEINS AND THE USE THEREOF TO TREAT EPITHELIAL OR ENDOTHELIAL MEMBRANE LEAKAGE INDUCED EDEMA
NORRIN REGULATION OF JUNCTION PROTEINS AND THE USE THEREOF TO TREAT EPITHELIAL OR ENDOTHELIAL MEMBRANE LEAKAGE INDUCED EDEMA
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机译:NORRIN对结蛋白的调节及其在治疗上皮或内皮细胞膜性水肿中的应用
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摘要
A method of tightening inter-cellular junctions in endothelial or epithelial cells includes exposing the endothelial or epithelial cells to a norrin in concert with an anti-VEGF agent. Upon sufficient contact time, for norrin to selectively up-regulate gene expression of Cadherin or claudin-5 in the endothelial or epithelial cells, the inter-cellular junctions are tightened.
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