A BIOMIMETIC FUNCTIONAL AND REGENERATIVE CARTILAGE IMPLANT

摘要

An artificial cartilage is provided whereby a fixed negative charged hydrogel has been infused within a restrictive swelling network, which limits and restricts the thickness of the artificial cartilage. At least 60% of the volume of the artificial cartilage is composed of the restricted and swollen hydrogel. The restrictive swelling network restricts the hydrogel to swell not more than 10% with respect to its maximum swelling capacity, i.e. a swelling capacity to swell 10-fold more is retained. The hydrogel within the restrictive swelling network has an equilibrium stiffness between 0.5 and 2 MPa to resist external loads applied to the top surface layer or the bottom surface layer of the artificial cartilage. The hydrogel has a fixed negative charge density of −0.17 to −0.23 mEg/ml and is capable of swelling between 2-15 times compared to the volume of the hydrogel without being restricted.