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CELL-BASED TREATMENT AND DRUG DISCOVERY IN HIRSCHSPRUNG'S DISEASE ENABLED BY PLURIPOTENT STEM CELL-DERIVED HUMAN ENTERIC NEURAL CREST LINEAGES
CELL-BASED TREATMENT AND DRUG DISCOVERY IN HIRSCHSPRUNG'S DISEASE ENABLED BY PLURIPOTENT STEM CELL-DERIVED HUMAN ENTERIC NEURAL CREST LINEAGES
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机译:多能干细胞源性人类肠道神经REST谱系在赫氏弹簧病中的基于细胞的治疗和药物发现
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摘要
The presently disclosed subject matter provides for in vitro methods of inducing differentiation of stem cells into enteric neural crest lineage cells, and enteric neural crest lineage cells by such methods. The presently disclosed subject matter also provides for uses of such enteric neural crest lineage cells for preventing and/or treating enteric nervous system disorders (e.g, Hirschsprung's disease), and for screening compounds suitable for preventing and/or treating enteric nervous system disorders (e.g., Hirschsprung's disease).
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