COMPOSITIONS COMPRISING RUMENIC ACID-RICH CONJUGATED LINOLEIC ACID FOR BRAIN HEALTH

摘要

Methods for treating or preventing age-related cognitive impairment in an adult human are disclosed. One method comprises administering to an adult human having, or at risk of having, impaired cognitive function a dietetic food, medical food, or food supplement. The food or food supplement comprises a rumenic acid-rich conjugated linoleic acid (RAR-CLA), or a pharmaceutically acceptable salt, ester, mono-, di-, or triglyceride, metabolic precursor thereof, or mixture thereof, in an amount effective to enhance cognitive function in the human. The RAR-CLA comprises cis-9, trans-11 linoleic acid and trans-10, cis-12 linoleic acid isomers in a weight ratio of at least 2:1. Enrichment of a dietetic food, medical food, or food supplement with RAR-CLA can help to improve cognitive function. The impact is particularly evident in aging adult males, as indicated by their improved scores in the Rey Auditory Verbal Learning Test. Longer-term studies will help to elucidate the potential impact of RAR-CLA on cognitive function in older adults, particularly in those with lower cognitive function.