Method for constructing animal model of obesity of non-human mammal or related diseases and use thereof

摘要

A method for constructing an animal model of obesity of a non-human mammal or a related disease, comprising: (a) providing a cell of the non-human mammal, inactivating the Glce gene in the cell, and inactivating the Glce gene A non-human mammal cell that has been transformed, and (b) an obesity animal or a related disease in which the Glce gene is inactivated by using the cell inactivated by the Glce gene obtained in step (a) And a method comprising manufacturing a model. The animal model is an effective animal model of obesity or related diseases, useful for studying diseases such as obesity, hyperlipidemia, hypertension, diabetes, and for screening and testing specific drugs. is there.