Tissue-specific markers for tissue localization and visualization before and during surgery

摘要

To make a pre-operative incision so that the surgeon is not removed with the adjacent or non-target tissue, or to prevent the adjacent or non-target tissue from being accidentally nicked, injured, or removed May face difficulties in selecting and identifying the target tissue during surgery for removal and identification or for identification. A tissue-specific marker can include an aptamer or affimer configured to bind to a preselected target tissue, and one or more indicator elements coupled to the aptamer or affimer. One or more indicator elements generate a signal, thereby enabling the identification of the target tissue in pre-operative and surgical manner.