In vitro neonatal biomimetic (NMMIC) models and methods and uses thereof

摘要

An in vitro biomimetic model of the neonatal immune cell system is provided, along with methods used in the preclinical evaluation of infant immune cell-mediated and humoral responses to immunogenic stimuli (eg, vaccination) using the model Is done. Examples of the model include those containing cord blood-derived follicular helper T cells and B cells, and those containing cord blood-derived dendritic cells and CD4 + T cells. For example, the model can be used to evaluate candidate vaccines via analysis of cellular responses to antigen and vaccine exposure.