Methods of improving the therapeutic index of anti-immune checkpoint agents by using a combination therapy comprising PHY906 extract, Scutellaria baicalensis George (S) extract, or a compound derived from such extract

摘要

The present invention comprises one or more immunizations with a therapeutically effective amount of PHY906 or a herb extract of Scutellaria baicalensis, a fraction thereof, or any of the active chemicals present in the herb extract or a fraction thereof. Provided are methods of treating melanoma and other cancers in a subject comprising administering a checkpoint inhibitor to a subject in need thereof. In certain embodiments, the method comprises extracting at least one herb from at least one herb selected from the group consisting of Glycyrrhiza uralensis, Peonia lactiflora, and Didiphas jujuba, or a fraction thereof, or It further comprises the step of administering any active chemical present in the herbal extract or fraction thereof. These methods of the invention are useful for treating cancers such as melanoma, non-small cell lung cancer, renal cell cancer, liver cancer, colon cancer, urothelial bladder cancer, and pancreatic cancer. It is. In certain embodiments, administration of the herbal extract of the invention suppresses gastrointestinal side effects of one or more of the immune checkpoint inhibitors and / or enhances their therapeutic index against cancer.