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Pharmaceutical composition and health functional food for preventing hyperphosphatemia and treating late adult kidney disease using Lactobacillus strain KCCM 11826P strain

机译：使用乳杆菌菌株KCCM 11826P菌株预防高磷血症和治疗晚期成人肾脏疾病的药物组合物和保健功能食品

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摘要

The present invention relates to a pharmaceutical composition for preventing or treating hyperphosphatemia kidney disease using Lactobacillus sp. Strain KCCM 11826P excellent in phosphorus absorption ability, and hyperphosphatemia kidney disease improvement It relates to health functional food for. According to the present invention, Lactobacillus sp. KCCM 11826 P selected according to the present invention is excellent in phosphorus absorbing ability, and can effectively inhibit phosphorus absorption into human body in the intestine. In addition, it can replace conventional calcium-based phosphorus binders and minimize the side effects caused by increased blood calcium concentration, thereby effectively preventing the aftereffects of hyperphosphatemia and kidney disease. Or can be treated. In addition, Lactobacillus sp. KCCM 11826 P selected according to the present invention can be taken at a very low price compared to existing phosphorus binders, and can be developed into yogurt, powder or a patient's nutritional diet due to the characteristics of the strain. Because it is, it is much more convenient to take than existing phosphorus binders.

机译：本发明涉及使用乳杆菌属（Lactobacillus sp）预防或治疗高磷酸盐血症性肾脏疾病的药物组合物。菌株KCCM 11826P具有极佳的磷吸收能力，并改善了高磷血症的肾脏疾病，涉及保健功能食品。根据本发明，乳杆菌属。根据本发明选择的KCCM 11826 P具有优异的磷吸收能力，并且可以有效地抑制肠道中磷向人体的吸收。此外，它可以代替传统的钙基磷结合剂，并最大程度地降低因血钙浓度升高而引起的副作用，从而有效地预防高磷血症和肾脏疾病的后遗症。还是可以治疗的。此外，乳酸杆菌。与现有的磷粘合剂相比，根据本发明选择的KCCM 11826 P可以以非常低的价格获得，并且由于菌株的特性，可以发展成酸奶，粉末或患者的营养饮食。因此，它比现有的磷粘合剂更方便服用。

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公开/公告号JP2019514420A

专利类型
公开/公告日2019-06-06

原文格式PDF
申请/专利权人コリアフードリサーチインスティチュート;カトリッククワンドンユニバーシティーインダストリーファウンデーション;
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申请/专利号JP20180560908
发明设计人キム;ヒョジン;ジャン;ヘウォン;チン;ヨン－ウク;カン;ウキョン;ムン;ソンジン;
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申请日2017-01-26
分类号A23L33/135;A61K35/747;A61P13/12;A61P3;C12N1/20;
国家 JP
入库时间 2022-08-21 12:22:13

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7. 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Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - 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An in vivo study349Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis in vitro and in vivo via EMMPRINEndothelium352Reciprocal regulation of GRK2 and bradykinin receptor stimulation modulate Ca2+ intracellular level in endothelial cells353The roles of bone morphogenetic proteins 9 and 10 in endothelial inflammation and atherosclerosis354The contribution of GPR55 to the L-alpha-lysophosphatidylinositol-induced vasorelaxation in isolated human pulmonary arteries355The endothelial protective ACE inhibitor Zofenoprilat exerts anti-inflammatory activities through H2S production356A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction357Endothelial progenitor cells to apoptotic endothelial cell-derived microparticles ration differentiatesas preserved from reduced ejection fractionheart failure358Proosteogenic genes are activated in endothelial cells of patients with thoracic aortic aneurysm359Endothelin ETB receptors mediate relaxing responses to insulin in pericardial resistance arteries from patients with cardiovascular disease (CVD)Smooth muscle and pericytes362CX3CR1 positive myeloid cells regulate vascular smooth muscle tone by inducing calcium oscillations via activation of IP3 receptors363A novel function of PI3Kg on cAMP regulation, role in arterial wall hyperplasia through modulation of smooth muscle cells proliferation364NRP1 and NRP2 play important roles in the development of neointimal hyperplasia in vivo365Azithromycin induces autophagy in aortic smooth muscle cellsCoagulation, thrombosis and platelets368The real time in vivo evaluation of platelet-dependent aldosterone prothrombotic action in mice369Development of a method for in vivo detection of active thrombi in mice370The antiplatelet effects of structural analogs of the taurine chloramine371The influence of heparin anticoagulant drugs on functional state of human platelets372Regulation of platelet aggregation and adenosine diphosphate release by d dimer in acute coronary syndrome (in vitro study)Oxygen sensing, ischaemia and reperfusion375Sirtuin 5 mediates brain injury in a mouse model of cerebral ischemia-reperfusion376Abscisic acid: a new player in cardiomyocyte protection from ischaemia?377Protective effects of ultramicronized palmitoylethanolamide (PEA-um) in myocardial ischaemia and reperfusion injury in vivo378Identification of stem cell-derived cardiomyocytes using cardiac specific markers and additional testing of these cells in simulated ischemia/reperfusion system379Single-dose intravenous metformin treatment could afford significant protection of the injured rat kidney in an experimental model of ischemia-reperfusion380Cardiotoxicity of long acting muscarinic receptor antagonists used for chronic obstructive pulmonary disease381Dependence antioxidant potential on the concentration of amino acids382The impact of ischemia-reperfusion on physiological parameters,apoptosis and ultrastructure of rabbit myocardium with experimental aterosclerosisMitochondria and energetics385MicroRNA-1 dependent regulation of mitochondrial calcium uniporter (MCU) in normal and hypertrophied hearts386Mitochondrial homeostasis and cardioprotection: common targets for desmin and aB-crystallin387Overexpression of mitofusin-2 (Mfn2) and associated mitochondrial dysfunction in the diabetic heart388NO-dependent prevention of permeability transition pore (MPTP) opening by H2S and its regulation of Ca2+ accumulation in rat heart mitochondria389G protein coupled receptor kinase 2 (GRK2) is fundamental in recovering mitochondrial morphology and function after exposure to ionizing radiation (IR)Gender issues392Sex differences in pulmonary vascular control; 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