Transdermal formulation and delivery method of low solubility or unstable non-ionized neutral drug by in situ salt-to-neutral drug conversion of salt drug

摘要

Compositions, devices, and methods are provided for transdermal administration of an active agent provided in a salt form rather than in a neutral form. In one aspect, a composition for transdermal delivery is provided. The composition comprises a drug reservoir comprising an active agent in salt form and a proton acceptor and / or proton donor. In one aspect, a composition for transdermal delivery is provided. The composition includes a drug reservoir comprising an active agent in amine salt form and a proton acceptor. In one embodiment, the active agent is donepezil, rivastigmine, memantine, fingolimod, or tamsulosin.