Prediction of Drug Solubility in Adhesive Matrix for Transdermal Drug Delivery Based on a Solvation Parameter Model

摘要

The work presented here establishes the relationship between drug solubility in two acrylate adhesives with a previously defined drug-polymer interaction parameter and drug solubility in acetonitrile. The drug solvation parameter model decomposes a hard-to-measure quantity into two easily measurable parameters. It is concluded that there is an excellent linear relationship for the parameters involved. Thus, the model can be used to compute the solubility in the polymer for new drug candidates. Moreover, the two parameters in the ralationship can be either easily measured or computed based on their molecular properties by the solvation parameter model. The methodologies presented can be applied to other adhesives.