Method of increasing the dispersion stability of nanoparticles as T1 MRI contrast agent and T1 MRI contrast agent nanoparticles

摘要

A method for increasing the dispersion stability of nanoparticles as T1 MRI contrast agents, and T1 MRI contrast agent nanoparticles are provided. Kind Code: A1 The present invention is a strategy for partially coating an existing contrast agent, in particular, a T1 contrast agent, in which a T1 contrast substance is partially coated on a surface exposed to a hydrophilic functional group. Is adopted. The partial coating strategy adopted in the present invention improves both the stability and the imaging ability of T1 contrast agent nanoparticles, which is a very interesting technological development. [Selected figure] Figure 1