Evaluation of intestinal barrier function to improve treatment of inflammatory bowel disease

摘要

In some embodiments, the present invention is a method of identifying a beneficial agent for treating a patient with inflammatory bowel disease: (a) determining the status of intestinal barrier in the patient; Group consisting of an anti-TNF agent and / or an anti-IL-12 / 23 agent classified as having severe dysfunction, including classifying the condition as severe dysfunction or moderate dysfunction. An anti-integrin agent, an anti-Janus kinase agent, and / or a sphingosine -1-, a patient identified as a patient who is expected to benefit from treatment with a drug selected from: and classified as having moderate functional impairment. Provided is a method, identified as a patient predicted to benefit from treatment with a phosphate receptor agonist agent.