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Assessment of Intestinal Barrier Function to Improve Treatment of Inflammatory Bowel Disease
Assessment of Intestinal Barrier Function to Improve Treatment of Inflammatory Bowel Disease
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机译:评估肠屏障功能以改善炎性肠病的治疗
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摘要
In some embodiments, the invention provides a method for identifying an agent beneficial to treat a patient with inflammatory bowel disease comprising: a) determining a status of an intestinal barrier in the patient; and b) categorizing the status as severe dysfunction or moderate dysfunction, wherein a patient categorized as having severe dysfunction is identified as a patient who will benefit from treatment with an agent selected from the group consisting of an anti-TNF agent and/or an anti-IL-12/23 agent, and a patient categorized as having moderate dysfunction is identified as a patient who will benefit from treatment with an anti-integrin agent, an anti-janus kinase agent, and/or and a sphingosine-1-phosphate receptor agonist agent.
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