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Novel 4-aminopyrazolo 3,4-d pyrimidinylazabicyclo derivatives and pharmaceutical compositions containing the same

机译:新型的4-氨基吡唑并[3,4-d]嘧啶基氮杂双环衍生物和含有该衍生物的药物组合物

摘要

The present invention relates to a 4-aminopyrazolo [3,4-d] pyrimidinylazabicyclo derivative and a pharmaceutical composition containing the same, and includes the 4-aminopyrazolo [3,4-d] pyrimidinylazabicyclo derivative and the same. The pharmaceutical composition not only has BTK inhibitory activity, but also has a significantly higher selectivity for BTK compared to ITK, and is useful as a BTK inhibitor for the prevention or treatment of autoimmune diseases or cancer. be able to.
机译:本发明涉及4-氨基吡唑并[3,4-d]嘧啶基氮杂双环衍生物及其药物组合物,包括4-氨基吡唑并[3,4-d]嘧啶基氮杂双环衍生物及其药物。与ITK相比,该药物组合物不仅具有BTK抑制活性,而且对BTK具有明显更高的选择性,并且可用作预防或治疗自身免疫性疾病或癌症的BTK抑制剂。能够。

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