Combinations of T cell checkpoint inhibitors with inhibitors of E-selectin or inhibitors of CXCR4 or with heterobifunctional inhibitors of both E-selectin and CXCR4

摘要

Heterobifunctional inhibition comprising a T cell checkpoint inhibitor comprising an E-selectin inhibitor, a CXCR4 receptor inhibitor, and / or at least one E-selectin inhibitor linked to at least one CXCR4 receptor inhibitor Disclosed are compositions and methods for the treatment of diseases, disorders, and / or conditions associated with increased regulatory T lymphocyte cell (Treg cell) function, comprising administering in combination with an agent. In one aspect, the disease, disorder, or condition is selected from a bacterial infection, a viral infection, a condition associated with at least one bacterial infection, and a condition associated with at least one viral infection.