Thieno and furo 2,3-d pyrimidine-2,4 1H, 3H -dione derivatives for the treatment of neuropsychiatric disorders as TRPC5 modulators

摘要

This invention relates to novel Thieno- and Furo[2,3-d]pyrimidine-2,4[1H,3H]-dione derivatives of formula I and their use as TRPC5 modulators, pharmaceutical compositions containing the same, and methods of using the same as agents for the treatment of TRPC5 receptor mediated disorders or conditions. A, R1, R2, R3 and R4 have meanings given in the description.