Uncatalyzed synthesis of furo(2,3-d)pyrimidine-2,4(1H,3H)-diones in water and their antimicrobial activity

摘要

Furo(2,3-d)pyrirnidine-2,4(1H,3H)-dione derivatives have been synthesized by environment-friendly three component condensation of cyclic 1,3-diketones, aromatic aldehyde, and aryl isocyanide under uncatalyzed conditions in water. The synthesized compounds have been tested for their antifungal and antibacterial activities. Most of the compounds exhibit good results against tested fungi and bacteria. The compound 5e has been found to be potentially active against Aspergillus oryzae while 5g show excellent zone of inhibition (39 mm) against Penicillium chrysogenum.