COMPOSITIONS COMPRISING HYPOXIA INDUCIBLE FACTOR-1 ALPHA AND METHODS OF USING THOSE COMPOSITIONS

摘要

To provide novel methods of treating the hypoxia or ischemia caused by critical limb ischemia, peripheral artery disease, wound healing, vascular disease, circulatory disease, coronary artery disease, cardiovascular disease, diabetes or the like.SOLUTION: Disclosed herein is a therapeutic comprising hypoxia inducible factor-1α (HIF-1α). Administration of the therapeutic can develop effect of promoting or inducing vascularization, increasing capillary density, promoting collateral vessel formation, increasing vessel size, and the like, and can increase tissue perfusion of affected tissues.SELECTED DRAWING: Figure 1