2-(2S) -1-Azabicyclo 2.2.2 oct-2-yl -6- (3-methyl-1H-pyrazol-4-yl) thieno 3,2-d pyrimidine-4 Crystalline form of (3H) -one hemihydrate

摘要

The present disclosure relates to 2-[(2S) -1-azabicyclo [2.2.2] oct-2-yl] -6- (3-methyl-1H-pyrazol-4-yl) thieno [3,2-d ] Crystalline form of pyrimidin-4 (3H) -one hemihydrate (compound 1) and / or its tautomer (compound 1 has the structure (I) .0.5H2O); compound 1 and / or its A process for preparing a tautomeric crystal form; a pharmaceutical composition comprising said crystal form; a method of inhibiting cell division cycle 7 in a mammal comprising administering said crystal form; and said crystal form or said crystal It relates to a method of treating cancer mediated by cell division cycle 7 in a mammal comprising administering a pharmaceutical composition comprising the form. [Selection figure] None