Composition for inducing differentiation into chondrocytes containing exosomes derived from stem cells differentiated into chondrocytes or for regeneration of cartilage tissue

摘要

The present invention relates to a composition for inducing chondrocyte differentiation or regenerating cartilage tissue including, as an active ingredient, an exosome derived from stem cells differentiating into chondrocytes; a medium composition for inducing chondrocyte differentiation, an injection preparation for regenerating cartilage tissue, and a pharmaceutical composition for treating cartilage disorders, all of which contain the composition; and a method for treating cartilage disorders. According to one specific embodiment of the present invention, the composition for inducing chondrocyte differentiation or cartilage regeneration includes, as an active factor, exosomes derived from stem cells differentiating into chondrocytes. Exosomes to be secreted during stem cell differentiation contain growth factors associated with chondrocyte differentiation, as well as genes and proteins associated with stem cell proliferation and regeneration, and thus the induction of regenerating damaged cartilage tissue is excellent according to the composition. In addition, the composition stably and rapidly delivers an active material, using the exosomes as cell-derived vehicles, into cells while minimizing side effects of conventional cell therapeutic agents. Therefore, a patient's pain can be reduced through a simple operation by means of an injectable composition for preventing and treating cartilage disorders, and the cartilage disorders can be continuously and effectively treated after the operation.