Pan-genotype drug against influenza virus and method of using the same

摘要

Methods of inhibiting influenza A virus in a sample are provided. Aspects of the method include contacting a sample comprising a viral RNA (vRNA) having a PSL2 motif with an effective amount of an agent that specifically binds to the PSL2 motif to inhibit influenza A virus. Also provided are methods of treating or preventing influenza A virus infection in a subject. Also provided is a method of screening candidate agents for the ability to inhibit influenza A virus in cells, the method comprising contacting the sample with the candidate agent and the candidate agent specifically binding to the PSL2 motif of the vRNA And to determine what to do. Also provided are compounds and pharmaceutical compositions comprising an oligonucleotide sequence that is complementary to the PB2 vRNA region that finds use in the subject methods. 【Selection chart】 None