Composition for the treatment of chronic lung diseases comprising exosomes derived from thrombin-treated stem cells

摘要

The present invention relates to a pharmaceutical composition for preventing or treating chronic lung disease, which comprises exosomes derived from thrombin-treated stem cells as an active ingredient, a pharmaceutical preparation containing the same, and a method for producing the same. According to the exosome-based therapeutic agent of the present invention, since it is a cell-free preparation, there is little risk of carcinogenesis, there is no problem of transplant rejection, and there is no risk of causing microvessels upon systemic administration. Because the drug development into an off-the-shelf product, which is a non-cellular separated substance, is possible, the manufacturing cost can be reduced, and the low concentration due to the thrombin treatment effect These exosomes have the advantage of being excellent in the therapeutic effect on chronic lung diseases.