Methods and systems for early risk assessment for preterm birth outcomes

摘要

Disclosed are systems and methods for assessing preterm birth risk for pregnancy subjects. Because existing preterm birth risk assessment methods provide results in the second or third trimester of late pregnancy, there is little time available for medical advice. The disclosed method and system predict preterm birth risk within 15 weeks of pregnancy. Microbiota characterization data are obtained from microbiota samples from pregnant subjects. The "Microbial taxonomic abundance profile" generated from the microbiota characterization data includes the abundance value of microbes present in the microbiota sample. Calculate the "Classification Construct Strain" value, which quantifies the deviation of the microbial abundance value from the microbial taxonomic abundance profile, and the distribution characteristic value of the "Microbial Taxonomic Abundance Profile". The risk of preterm birth is determined based on the distribution characteristic values or "taxonomically constructed strain" values of the set DSR, the set DSR including a value that quantifies the bias of microbial abundance values from the microbial flora sample. [Selected figure] Figure 2