C14 hydroxyl esterified amino acid derivative of triptolide, and its preparation and use

摘要

The present invention belongs to the fields of natural medicine and medicinal chemistry and is a novel, esterified amino acid derivative of triptolide of general formula I and general formula II or a pharmaceutically acceptable adduct, complex, salt, and catabolism thereof. Products and metabolites, methods for producing these compounds, pharmaceutical compositions comprising such compounds and those in the manufacture of drugs for tumors, immune diseases, or diseases associated with abnormal expression of XPB or Pol II or the oncogene c-myc About the use of.