C14-hydroxyl esterified amino acid derivatives of triptolide, and preparation method and use thereof

摘要

The present invention belongs to the field of natural pharmaceuticals and pharmaceutical chemistry, and relates to novel esterified amino acid derivatives of triptolide of general formulae I and II or a pharmaceutically acceptable adduct, complex, salt and catabolites and metabolites thereof, and a method for preparing these compounds, a pharmaceutical composition containing the compound, and a use thereof in the preparation of drugs for against tumours, immunological diseases, or diseases associated with abnormal expressions of XPB or Pol II or oncogene c-myc.