A secreted splicing variant of mammalian Klotho as a drug for cognitive and behavioral disorders

摘要

The present invention discloses the use of a secreted splicing variant (s-KL) of mammalian Klotho as an agent for the prevention and / or treatment of cognitive and / or behavioral disorders. The present invention also refers to gene constructs and expression vectors useful in gene therapy for delivery of the s-KL variant to the mammalian, particularly rodent or human central nervous system. Also disclosed are pharmaceutical compositions comprising protein s-KL or any gene construct for expressing a protein in the CNS.