Heterodimeric molecule based on CH3 domain, its preparation method and use

摘要

Heterodimeric molecules based on CH3, their preparation and use. By considering the various interactions between molecules such as ionic action, hydrophobic interaction and spatial action, a suitable Fc variant sequence that has a greater tendency to form heterodimers without forming homodimers As a result, the production amount of heterodimeric molecules was greatly improved, and conditions were prepared for the preparation of bispecific molecules and the like. [Selection] Figure 3